New preprint on hypoxia and myeloid responses in glioblastoma

Pekka and Masi contributed to a new bioRxiv preprint on how hypoxia and acidosis shape myeloid cell responses in glioblastoma, led by Kirsi Rautajoki’s team. The study combines cyclic immunohistochemistry, single-cell RNA sequencing, spatial transcriptomics and DNA methylation profiling across 136 glioblastomas, showing that infiltrating macrophages adapt to survive acidic hypoxic niches while microglia are depleted there and lose their homeostatic identity.